Abstract
Plants continue to be a major source of medicines, as they have been throughout human history. Ocillium basilicum has been used since ancient times as a medicine and food and it is known that the antioxidant effect of O. basilicum is beneficial to protect tissue and decreasing carcinogeniceffect of electromagnetic field (EMF), so it was hypothesized that this herb might also provide protection to ovarian tissue against reactive oxygen spaces (ROS). Female wistar rats (n = 40) were allocated to four groups, a control group (n = 10) and three treatment groups (n = 30). The first treatment group received O. basilicum extract (1.5 g/kg body weight), the second extract group received O. basilicum extract (1.5 g/kg body weight) and EMF exposure at 50 Hz for 40 consecutive days, whilst the third group received only EMF exposure for 40 consecutive days. At the conclusion of the test period, rat ovary tissues were removed from all group members. Ovary tissue preparation was performed and analyzed for apoptosis. There was a significant increase in apoptosis in EMF group when compared with other groups (P<0.05). EMF has negative effect on ovary histology in rats by increasing fibrosis and vein congestion. However, these side effects are less seen in the EMF group that received O. basilicum extract. Usage of O. basilicum extract could be one of the useful methods as antioxidant therapy against EMF exposure in industrial area. Key words: Apoptosis, electromagnetic field (EMF), fibrosis, Ocimum basilicum, ovary.
Highlights
Herbs help to protect cells from the damaging effects of oxidation
Ovarian apoptotic granulosa cells percentage significantly decreased following administration of O. basilicum extract (1.5 g/kg body weight) in comparison to the control group(P
Obtained result indicates the protective effect of O. basilicum against electromagnetic field (EMF)- induced granulosa cells apoptosis
Summary
Herbs help to protect cells from the damaging effects of oxidation. Factors like stress, aging, electromagnetic field (EMF) and pollution causes’ high level of free radicals in body which damage DNA and causes many diseases such as infertility. An EMF or EM field is a physical field produced by electrically charged objects. Many researchers confirmed the observation of the previous studies that the remainder of the cohort undergoes atresia by uncertain stimuli and mechanisms. It appears that growth factors and related peptides may be involved in this process (Wei and Giudice, 1997). The present study was designed to investigate the protective effects O. basilicum as anti-oxidant on EMF effects on ovary cells apoptosis
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