Abstract
The objective of this study was to investigate the effects of crude polysaccharides from Purslane (PFP) supplementation on fatigue induced by forced swimming in mice. 96 mice were divided randomly into four groups: Control group (CG), low-dose PFP supplemented group (PFP-LG), middle-dose PFP supplemented group (PFP-MG) and high-dose PFP supplemented group (PFP-HG). Each group contains 24 animals. All were administered orally and daily for 4 weeks. Control group received isotonic saline solution (50 ml/kg bodyweight); and supplemented groups orally obtained 100, 200 and 400 mg/kg bodyweight of PFP in appropriate volumes of physiological saline. Changes of the body weights of the mice were observed during initial and terminal stages of the experiment along with the swimming capacity and corresponding biochemical parameters including blood lactic acid (BLA), serum urea nitrogen (SUN) and hepatic glycogen. The results of this study showed that PFP supplementation could extend the swimming time to exhaustion of the mice, as well as increase the hepatic glycogen contents, while decreasing the BLA and SUN contents. These indicated that PFP could alleviate fatigue induced by forced swimming in mice. Key words: Crude polysaccharides from Purslane, fatigue, forced swimming, mice.
Highlights
Fatigue is an everyday phenomenon, which we all experience
The objective of this study was to investigate the effects of crude polysaccharides from Purslane (PFP) supplementation on fatigue induced by forced swimming in mice. 96 mice were divided randomly into four groups: Control group (CG), low-dose PFP supplemented group (PFP-LG), middle-dose PFP supplemented group (PFP-MG) and high-dose PFP supplemented group (PFP-HG)
The results of this study showed that PFP supplementation could extend the swimming time to exhaustion of the mice, as well as increase the hepatic glycogen contents, while decreasing the blood lactic acid (BLA) and serum urea nitrogen (SUN) contents
Summary
It is difficult to define fatigue since it is not a uniform phenomenon and has various appreciations depending on the context. Exercise promotes consumption of energy sources, such as glycogen, by mobilizing internal energy metabolism to the maximum and using and depleting the energy source. Through these processes, exercise causes the production and accumulation of products of metabolism, such as lactic acid, in the body (Ikeuchi et al, 2006; Kim et al, 2008; Ding et al, 2010).
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