Year-end Sale % OFF 
Abstract
Loiasis infection is characterised by long term stability in infection status. The bases of such stability are not well known. As preliminary step toward verification of possible genetic involvement in this stability, a survey in a homogeneous population (n = 106) of a village from an endemic zone of Gabon was undertaken. The distribution of Loa loa microfilaremia according to age revealed a significant relationship between age and the presence of microfilariae in the blood (p = 0.0059). The proportion of microfilaremic individuals increased with age until 45 years old, and did not exceed 34% as its maximum. The other marker (specific IgG4) increased also significantly with age (p = 0.0038), but in contrast to microfilaremia, the prevalence of specific IgG4 in the group from 45 years onward reached 100%. These observations show the importance of age for the definition of the amicrofilaremic or microfilaremic individual status in an endemic area and are in agreement with the hypothesis suggesting the existence of genetic factors controlling the outcome of the parasitological status in L. loa infection. Key words: Loa loa, prevalence, age, IgG4, genetic.
Highlights
Loiasis is cause by the human filarial Loa loa which is endemic in the west and Central African forest block
Epidemiological studies have shown the diversity of infection status and the microfilaraemic status was used for long time to define loiasis (Richard-Lenoble, 1980)
Following the dynamic of specific IgG4 (Figure 1, sero prevalence curve), the seroprevalence was already high between 6 and 15 years age (55.26%), but continued to increase to reach 100% of individuals at 45 years and above
Summary
Loiasis is cause by the human filarial Loa loa which is endemic in the west and Central African forest block. An estimated 10 millions individuals are thought to harbour the parasite (Sasa, 1976; Akue et al, 2011; Zouré et al, 2011) and in some regions, the loiasis is the second cause of hospital consultation after malaria (Boulestiex and Carme, 1986). The treatment available (diethylcarbamazine citrate and Ivermectine) are mostly active on circulating microfilariae (Richard-Lenoble et al, 1988). A better understanding of this infection in human population from endemic area is required in order to elaborate new strategy for its control. Epidemiological studies have shown the diversity of infection status and the microfilaraemic status was used for long time to define loiasis (Richard-Lenoble, 1980). It is admitted today that some are infected without any
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
