Abstract
The fungicide Maneb is a member of the family of dithiocarbamates that is used in the control of the fungal diseases of plants. The purpose of this work is to examine the effect of Maneb on implantation and thyroid activity at doses of 5, 10 and 50 mg/kg/day by gavage for 10 days in the domestic female rabbit, Oryctolagus cuniculus. The rabbits were sacrificed on the 11th day of pregnancy. The results indicate an increase in the body weight in the treated female. An increase is also observed in the weight of liver in the treated females with a darker color. There is 50% of inhibition of implantation in the group treated with the higher dose (50 mg/kg/day) when compared with control rabbit. The inhibition of implantation by Maneb may be to due to hormonal imbalance.
Highlights
As a chemical family, the ethylenebisdithiocarbamate (EBDC) pesticides are regarded as fungicides with a wide range of uses including many fungal diseases of vegetables, fruits, and field crops
Twenty four pregnant female rabbits of initial body weight of 1100 2500 g were divided into three treated groups and six females were used as control
At the end of the period treatment, two rabbits died in the treated group with 50 mg/kg
Summary
The ethylenebisdithiocarbamate (EBDC) pesticides are regarded as fungicides with a wide range of uses including many fungal diseases of vegetables, fruits, and field crops. They have been on the market since the 1930s and 1940s. The organometallic fungicide, Maneb, is widely used in agriculture to protect against a wide spectrum of fungal diseases many fruits, vegetables and nuts. Maneb has a low acute toxicity but high or repeated exposures may interfere with gonads and thyroid functions (Bharati and Basappa, 2002). Few studies have been carried out on the chronic toxicity of dithiocarbamates containing heavy metals such as manganese (Mn) and zinc (Zn). Ethylene thiourea (ETU) is major metabolite of ethylenebisdithiocarbamate fungicides which has been reported to be carcinogenic, teratogenic, and mutagenic in experimental animals (Teramoto et al, 1975; Larsson et al, 1976; Tanaka et al, 1995)
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