Abstract
OBJECTIVE:- The aim of the study was to determine the efficacy of combination of vitamin K2+ vitamin D3+calcium in prevention of osteoporosis in osteopenic postmenopausal women . MATERIALS AND METHODS: This study included 60 postmenopausal osteopenic women. They were divided in two groups one group were administered 1gm calcium+ vitamin D3 1 mcg /day and other group were administered 1gm calcium+ vitamin D3 1mcg+vitamin K2 45mg/day. All the patients were investigated for bone marker undercarboxilated osteocalcin, N Telopeptide and bone mineral density. RESULTS: It was observed that group I that was treat with vitamin D3+calcium had less percentage improvement in bone mineral density and reduction of undercarboxilated osteocalcin and N telopeptide in comparison to patients who were treat with vitamin K2+vitaminD3+calcium observed had more percentage improvement in bone mineral density and reduction of undercarboxilated osteocalcin and N telopeptide. CONCLUSION-According the results of this study vitamin K2 to be more effective as a protective agent than combined calcium and vitamin D3 administration in cases of osteoporosis. KEY WORD : osteoporosis, osteopenia, vitamin K, vitamin D, BMD, uc(OC) N telopeptide.
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