Abstract
The process of microwave-assisted extraction (MAE) of total flavonoids from corn silk and the hypolipidemia in animal models were studied. Influence of solvent concentration, microwave power, extraction time and dose of solvent were investigated and then, the orthogonal experiments were performed. Animal models of hyperlipidemia induced by high-fat diet were established. The serum levels were respectively measured, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). The optimum extraction parameters were determined as follows: the ethanol concentration (60%); the power (600 W); the extraction time (16 min); the ratio of plant material to solvent (M/S) (1:20), and the yield of extract (4.55%). Corn silk total flavonoids (CSTF) significantly lowered the serum TC, TG and LDL-C levels. The serum lipid level was decreased by CSTF in hyperlipidemic animal models in a dose dependent manner. Key words: Corn silk, total flavonoids, microwave-assisted extraction (MAE), antihyperlipidemia.
Highlights
Corn silk is the style and stigma of Zea mays Linne
The total flavonoid content is reported that Corn silk total flavonoids (CSTF) has many pharmacological effects, such as antioxidative and hypoglycemic effects
We observed the effect of CSTF on metabolism of cholesterol and lipoprotein-cholesterol in the experimental hyperlipidemia rats, to prove if CSTF is beneficial to prevent or treat AS
Summary
Corn silk is the style and stigma of Zea mays Linne. Currently, only a small amount is used as medicine and most is thrown away as waste. Flavonoids from stigma maydis were reported to scavenge hydroxyl, regulate lipid metabolism in mice, and have anti-aging and anti-fatigue effect. The extraction of corn silk total flavonoids (CSTF) was studied for the development of corn silk as natural food antioxidants and natural medicine. It has an important economic value and social significance. Antihyperlipidemic activities of CSTF were was determined as an indicator of the optimal process To control hyperlipo-proteinemia, the key method is to prevent or treat AS and CHD. We observed the effect of CSTF on metabolism of cholesterol and lipoprotein-cholesterol in the experimental hyperlipidemia rats, to prove if CSTF is beneficial to prevent or treat AS
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