Abstract
The extract of Terminalia macroptera Guill. & Perr. has been used in the management of pile and other ailments across West Africa. This has necessitated the evaluation of the toxicity of this plant in Sub-chronic and acute administration as well as heavy metal analysis. The root of T. macroptera was extracted with ethanol and analyzed for the presence of phytochemicals. The powdered root was digested and analyzed for presence of Cd, Cr, Pb, Ni and Zn using spectrophotometric technique. The sub-acute toxicity on some liver parameters was evaluated following the administration at doses of 1.5, 1.0 and 0.5 g/kg respectively. The phytochemical screening of the extract revealed the presence of alkaloids, flavonoids, steroids, glycoside, resins and saponin. No death of a single animal was recorded after the acute toxicity study. The effect of sub-chronically administered extract was P< 0.05 of ALT, AST and ALP at different doses when compared to the control. The quantity of metal detected was; Cd (0.0830 ppm), Cr (0.3516 ppm), Pb (0.8809 ppm), Ni (0.6438 ppm) and Zn (0.7340 ppm), which are all within the normal range (1 ppm) as recommended by the Federal Ministry of Environment, Nigeria. Key words: Acute toxicity Heavy metals phytochemicals Terminalia macroptera Guill. & Perr., Sub-chronic toxicity.
Highlights
Terminalia macroptera Guill. & Perr. (Combretaceae) is a tree, up to 20 m high, which occurs widely in West Africa
In Mali T. macroptera is used against a variety of ailments, and more than 30 different indications have been mentioned by the traditional healers in ethnopharmacological studies
The roots are used against hepatitis, gonorrhea and various infectious diseases, including Helicobacter pylori -associated diseases (Silva et al, 2012, 2000)
Summary
Toxicity study of ethanol root extract of Terminalia macroptera Guill. & Perr. (Combretaceae) and assessment of some heavy metals. Toxicity study of ethanol root extract of Terminalia macroptera Guill. Has been used in the management of pile and other ailments across West Africa. This has necessitated the evaluation of the toxicity of this plant in Subchronic and acute administration as well as heavy metal analysis. The root of T. macroptera was extracted with ethanol and analyzed for the presence of phytochemicals. The powdered root was digested and analyzed for presence of Cd, Cr, Pb, Ni and Zn using spectrophotometric technique. The sub-acute toxicity on some liver parameters was evaluated following the administration at doses of 1.5, 1.0 and 0.5 g/kg respectively.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
