English

Abstract

Introduction: Vulvovaginitis candidiasis is one of the common problemsencountered by females and accounts for one third of vaginitis cases. Objective: To studythe efficacy of oral treatment with fluconazole in vulvovaginits candidiasis. Study Design:Descriptive case series. Setting: This study was conducted in the Department of Gynaecology,Lahore General Hospital, Lahore and Shalamar Hospital Lahore. Duration with Dates: Sixmonths from October 2009 to March 2010. Subjects and Methods: One hundred and twentyfive patients fulfilling the inclusion criteria were selected for this study. Demographic historyregarding name, age and parity, etc. were taken. Patients received fluconazole 150mg aftertaking smear for microscopy and culture carried out in Lahore General Hospital laboratoryand then Shalamar Hospital laboratory. All patients were reevaluated after 2 weeks for clinicaland mycological cure by taking the history and repeating smear for microscopy and culture.Results: The mean age of the patients was 31.4+ 6.4 years. The mean duration of marriage ofthe patients was 8.7+6.2 years. There were 11 (8.8%) patients of 0 parity, 63 (50.4%) patientsof parity range of 1-2, 41 (32.8%) patients had parity range of 3-4 and 10 (8%) patients had 5-6parity range. 99 (79.2%) patients had clinical cure. There was good efficacy of 79.2% and 26.8%patients failed to show the response. Conclusion: From this study fluconazole 150mg is provedto be safe and effective for the treatment of volvovaginitis candidiasis but therapy of vaginitisshould be individualized, taking into consideration severity of disease, history of vaginitis, andpatient preference.