English

Abstract

There are acute and chronic forms of hepatitis, which may result in nausea, jaundice, fatigue and abnormal liver function blood tests. Acute hepatitis is characterized by the parenchymal liver damage by any agent on an underlying normal liver which produces similar clinical and biochemical features. Chronic hepatitis is defined as hepatic necro- inflammation continuing for more than 6 months. Liver disease is often associated with an increased prevalence of impaired glucose tolerance and diabetes mellitus. The effect of HbA1c on Acute and Chronic liver diseases is not well studied. The present study is to know whether acute and chronic liver diseases have same effect on HbA1c or different effects on HbA1c and also to know the enzyme levels (ALT, AST and ALP) in these cases. OBJECTIVES: To study the effect of Acute Liver Disease and Chronic Liver Disease on Glycated hemoglobin (HbA1c), Alanine transaminase (ALT), Aspartate transaminase (AST) and alkaline phosphatase (ALP) levels. METHODS: A total number of 80 patients diagnosed and treated by Medical Department were taken for the study. Out of 80 patients, acute liver disease patients were 40 and Chronic liver disease patients were 40. Forty people who are age and sex matched, apparently healthy normal subjects were also studied as controls. Samples were analyzed for HbA1c, Alanine Transaminase (ALT), Aspartate transaminase (AST) and alkaline phosphatase (ALP). Statistical analysis: It is case control study. Analysis was done by Student's 't' test using Grphpad software. RESULTS: HbA1c values of acute liver disease shows no statistical significance when compared with controls. But HbA1c of Chronic liver disease shows statistical significance when compared with control. ALT, AST and ALP values of acute liver disease and chronic liver disease when compared with control shows very high significance. CONCLUSION: Chronic liver disease group shows significant increase in HbA1C when compared with control group, which may be due to endogenous insulin resistance which causes impaired glucose tolerance. Chronic liver disease has significant impact on hepatic glucose metabolism. ALT, AST and ALP values of Acute and Chronic liver diseases increased and show very high significance due to Liver disease and biliary obstruction in certain cases.