Abstract
Since the discovery of Helicobacter pylori in 1983 by Robin Warren and Barry Marshall, the diagnosis and treatment of upper gastrointestinal disease have changed greatly. As infection with H. pylori is the strongest known risk factor for gastric cancer, that is why our study was undertaken in our surgery department to establish the role of H. pylori in patients of gastric cancer in Southern Odisha. Total 70 patients of gastric cancer as cases and 32 controls were studied. H. pylori infection status in all cases and controls was assessed by serological test, rapid urea broth test and histopathological examination of the gastric mucosal biopsy specimens. H. pylori infection was positive in 64 cases of cancer stomach (91.43%) and 24 patients were positive in the control group (75%). The odds ratio was estimated to be 3.56 and p. value was found to be < 0.02.
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