Abstract
This study was designed to evaluate the preventive potentials of vitamin E and glibenclamide on spermatogenic and haematological damages in alloxan-induced diabetic male rats. Thirty mature male albino rats randomly assigned into 5 groups (n=6) were used for the study. Diabetes was experimentally induced in groups 1 to 4 while group 5 rats served as the negative control. Rats in groups 1, 2 and 3 were treated with glibenclamide, glibenclamide+Vitamin E, and Vitamin E, respectively while rats in group 4 served as the diabetic (positive) control. Results showed that percentage sperm motility was significantly higher (p<0.05) in groups 2 and 3 compared to group 1. Rats in group 2 recorded significant increases (p<0.05) in testicular weight, epididymal sperm reserve and testicular sperm reserve compared to groups 3 and 4, respectively. Rats of group 2 also had significantly higher packed cell volume and red blood cell counts compared to groups 1 and 3. Results from the study showed that combination of vitamin E and glibenclamide had optimum protective potential on the physiological parameters evaluated. Key words: Diabetes, vitamin E, glibenclamide, spermatogenic changes, haematology, albino rats.  
Highlights
Diabetes mellitus commonly referred to as diabetes is a disease associated with hyperglycemia due to insufficient production of insulin or inability of cells in the body to respond appropriately to available insulin (Rother, 2007)
In rats treated with a combination of glibenclamide and vitamin E, the mean Packed cell volume (PCV) and mean RBC were significantly increased compared to rats with either glibenclamide only or vitamin E only
There was a significant decrease in white blood cells of diabetic control compared to glibenclamide and glibenclaminde + Vitamin E-treated groups
Summary
Diabetes mellitus commonly referred to as diabetes is a disease associated with hyperglycemia due to insufficient production of insulin or inability of cells in the body to respond appropriately to available insulin (Rother, 2007). It affects man as well as animals.
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