Abstract
The purpose of the present study was to examine the effects of aqueous extract of Salvia miltiorrhiza on plasma lipid and hydroxyproline levels and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats. Adult Sprague-Dawley male rats, 3 months of age, were assigned randomly to a sedentary control (n = 10) or exercise (n = 10) group or SME-treatent groups (exercise + SME) (n = 10 in each group). Ten animals in sedentary control group did not receive any exercise. Animals in exercise group received exercise. Animals in SME-treatent groups (exercise + SME) received exercise orally given withS. miltiorrhiza extract (50, 100 or 150 mg/kg body weight), respectively. Result showed that aqueous extract of S. miltiorrhiza can decrease blood total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) and increase high-density lipoprotein cholesterol (HDL-c) levels, enhance hydroxyproline levels in bone, skeletal muscle, heart and lung, and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats. Key words: Salvia miltiorrhiza, exercise, rat, blood lipid.
Highlights
Salvia miltiorrhiza Bunge (Danshen root) is a well-known plant used in traditional Chinese medicine to treat various entities, such as cardiovascular disease, angina pectoris, hyperlipidemia and acute ischemic stroke (Zhou et al, 2005; Cheng, 2007)
The purpose of the present study was to examine the effects of aqueous extract of Salvia miltiorrhiza on plasma lipid and hydroxyproline levels and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats
Result showed that aqueous extract of S. miltiorrhiza can decrease blood total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) and increase high-density lipoprotein cholesterol (HDL-c) levels, enhance hydroxyproline levels in bone, skeletal muscle, heart and lung, and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats
Summary
Salvia miltiorrhiza Bunge (Danshen root) is a well-known plant used in traditional Chinese medicine to treat various entities, such as cardiovascular disease, angina pectoris, hyperlipidemia and acute ischemic stroke (Zhou et al, 2005; Cheng, 2007). Danshen extracts contain several constituents including water soluble phenolic acids and lipophilic tanshinones (Wang et al, 2007). Danshen contains the lipid-soluble tanshinone I (Tan I), tanshinone IIA (Tan IIA), cryptotanshinone and dihydrotan-shinone as well as the water-soluble danshensu and salvianolic acid B (Sal B) (Adams et al, 2006). Danshen inhibits platelet aggregation and promotes fibrinolysis (Zhou et al, 2005; Chan, 2001). There have been discrepancies among the studies investigating the peroxidative effects of physical exercise. This has been attributed partly to the various methods used to evaluate lipid peroxidation and partly to the exercise model or characteristics of the subjects chosen in these studies (Dekkers et al, 1996)
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