English

Abstract

OBJECTIVE: To study assess the impact of amitriptyline in patients with MPDS. MATERIAL AND METHODS: Hundred patients diagnosed to have MPDS for the first time, between the age group 18-60 years were included. Patients were diagnosed based on their symptomatology and their clinical findings. They were started on Amitriptyline 25mg at night for a minimum period of 3 months and the clinical improvement was noted. STUDY DESIGN: It was a prospective study where the relief of the symptoms was assessed before and after treatment using mean, frequency, standard deviation and paired 't' test. RESULT: A total of 100 patients with MPDS who were treated with amitriptyline were studied. The study showed a female preponderance. MPDS was seen more common in patients with stress. Pain relief with usage of amitriptyline was seen in 85% of patients. The student 't' test should p value of <0.005 which was significant. CONCLUSION: Treatment of MPDS with amitriptyline for 3 months reduced the severity of symptoms. However the long term effects on quality of life could not be assessed. The study needs to be conducted in a large scale to evaluate the