Abstract
In order to evaluate the effects of methamphetamine on sexual behavior of fish, saltwater-acclimatized male sailfin molly Poecilia latipinna L. (Pisces) adults were exposed to 0.1, 0.5, 1 mg/L methamphetamine (MA) concentrations and were observed for alterations in sexual behavior at 2nd, 5th or 7th exposure days. The overall changes displayed by the subjected fish included different acute and chronic responses. Key words: Methamphetamine (N,α-dimethylphenethylamine), fish, sexual behavior, male.
Highlights
Methamphetamine (N, -dimethylphenethylamine, C10H15N, “MA”) is a prototypical basic drug (Logan, 2002)
Our results show that acute exposure to MA can result in sexual arousal in male fish
D1 and D2, DA receptors are clearly implicated in the induction of sexual arousal (Da prada et al, 1973) and it has been suggested that presynaptic activation of DA transmission is a key pharmacologic property mediating the sex-promoting effects of stimulants (Pagllietti et al, 1978)
Summary
Methamphetamine (N, -dimethylphenethylamine, C10H15N, “MA”) is a prototypical basic (pKa 9.9) drug (Logan, 2002). It is a central nervous system (CNS) stimulant and its potent stimulating effects appear to result by promoting the release of biogenic amines from their stores in the nerve terminals, together with dopamine (DA) release from dopaminergic nerve terminals (Elsohly et al, 1992). These effects can result in arrhythmia, vasculature constriction and delayed ejaculation and enhanced intensity of orgasm in male human (Perez-Reyes et al, 1991; Logan, 2002; Ellinwood and Kilbey, 1980). The present study used a comprehensive approach to examine the effects of MA exposure on sexual behavior fish to examine if the fish can be used as appropriate model for studying behavioral effects of MA in human
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