Abstract
Chemical investigation of ethyl acetate leaf-extract of Pterocarpus santalinoides led to isolation of a friedelane-terpenoid. Structure elucidation was done by comparison of the Nuclear Magnetic Resonance (NMR) spectral features with literature data and was consistent with reported values for friedelan-3-one. The following microorganisms (Clinical isolates): methicillin resistant Staphylococcus aureus (MRSA), S. aureus, Corynebacterium ulcerans, Streptococcus pneumoniae, Campylobacter jejuni, Helicobacter pylori, Escherichia coli, Shigella dysenteriae, Candida tropicalis and Candida krusei were used for the in vitro antimicrobial activity. The isolated compound had Minimum Inhibition Concentration (MIC) value of 10 µg/ml for MRSA, H. pylori, E. coli and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) of 40 µg/ml for E. coli; 20 µg/ml for MRSA, H. pylori and C. krusei; 10 µg/ml for S. aureus, S. pneumonia and C. tropicalis. It showed moderate antimicrobial activity against most of the pathogens tested. This is also the first report of the isolation of friedelan-3-one from this species. Key words: Friedelan-3-one, methicillin resistant Staphylococcus aureus (MRSA), Helicobacter pylori, Escherichia coli.
Highlights
Plant based traditional medicine systems have continued to play an essential role in the health care of many cultures
Chemical investigation of ethyl acetate leaf-extract of Pterocarpus santalinoides led to isolation of a friedelane-terpenoid
Structure elucidation was done by comparison of the Nuclear Magnetic Resonance (NMR) spectral features with literature data and was consistent with reported values for friedelan-3-one
Summary
In vitro antimicrobial properties of friedelan-3-one from Pterocarpus santalinoides L’Herit, ex Dc. Ichiko Chic Odeh, Terrumun Amom Tor-Anyiin2*, John Ogbaji Igoli and John Vershima Anyam. The isolated compound had Minimum Inhibition Concentration (MIC) value of 10 μg/ml for MRSA, H. pylori, E. coli and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) of 40 μg/ml for E. coli; 20 μg/ml for MRSA, H. pylori and C. krusei; 10 μg/ml for S. aureus, S. pneumonia and C. tropicalis. It showed moderate antimicrobial activity against most of the pathogens tested. This is the first report of the isolation of friedelan-3-one from this species
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
