Abstract
Parthenium hysterophorus is used as a vegetable and in the treatment of various human ailments traditionally in Pakistan. The current study was arranged to investigate the nutritional importance, microbial inhibition and its potency against free radicals. The results revealed that extract possesses macro elements Ca, K, Na, Mg, Fe, Zn, as well as micro elements including Ni, Li, Pb, Co, Mn, Cu, Cr, and Cd. Scavenging of free radicals revealed that methanolic extract of P. hysterophorus (PM) possesses lowest IC50 (2.5 ± 0.05 μg/ml) comparatively to ascorbic acid (3.7 ± 0.03) and n-hexane extract of P. hysterophorus (PH) (5.1 ± 0.07 μg/ml). The extracts also showed maximum antibacterial potential in various concentrations of n-hexane and methanolic extract of P. hysterophorus. The results revealed that P. hysterophorus contain a remarkable fungal inhibition due to the presence of bioactive constituents. Based on this screening various fractions of P. hysterophorus are recommended for future bioassay guided isolation of bioactive constituents. Key words: Parthenium hysterophorus, nutritional analysis, antimicrobial activity, 1,1-diphenyl 1-2-picryl-hydrazyl (DPPH).
Highlights
Plants possess a number of bioactive compounds which are used as medicine or in preparation of new drugs
The results revealed that P. hysterophorus contain a remarkable fungal inhibition due to the presence of bioactive constituents
The digestion method revealed that P. hysterophorus possessed highest concentration of macro elements in μg/g of Ca (75.14 ± 0.45), K (29.09 ± 0.21), Na (11.37 ± 0.14), Mg (6.161 ± 0.31), Fe (7.36 ± 0.01) and Zn (4.63 ± 0.009), as well as micro elements including Ni (0.056 ± 0.0005), Li (0.081 ± 0.004), Pb (0.45 ± 0.002), Co (0.69 ± 0.003), Mn (0.089 ± 0.003), Cu (0.096 ± 0.002), Cr (0.098 ± 0.002) and Cd (0.54 ± 0.005) dry powder
Summary
Plants possess a number of bioactive compounds which are used as medicine or in preparation of new drugs. Many efforts have been made to extract new antimicrobial bioactive compounds from various kinds of sources One of such resource is fractions of folk medicinal plants. In ancient times people used spices and herbs in their food as flavoring agents (Beuchat, 1994; Cutler, 1995; Khan et al, 2009; Khan et al, 2011) These can be used locally as food preservatives and in folk medicine . Many herbs and spices possessed free radical scavenging, antioxidant and antimicrobial activities like bactericidal and bacteriostatic Worldwide, many medicinal plants, spices and herbs, exert antimicrobial activities. The present study was undertaken to investigate the free radical scavenging and antimicrobial efficacy of P. hysterophorus
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