Abstract
In this investigation, antihyperglycemic and antioxidant potential of oil of seeds of Arachis hypogaea (AHO) in streptozotocin-nicotinamide (STZ) induced type 2 diabetic rats was observed along with gas chromatography flame ionization detector (GC-FID) analysis. AHO was orally administered to diabetic rats to study its effect in both acute and chronic antihyperglycemic study. The body weight, oral glucose tolerance test and biochemical parameters: glucose level, insulin level, liver glycogen content, glycosylated hemoglobin and antioxidant parameters were estimated for all treated groups and compared against diabetic control group. GC-FID analysis showed the presence of major constituents as oleic acid (48.4500%), linoleic acid (32.6355%), palmitic acid (12.6988%) and arachidic acid (4.0814%). AHO (500 and 1000 mg/kg) and glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin-nicotinamide induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose and glycosylated hemoglobin in test groups as compared to control group. In vivo antioxidant studies on STZ-nicotinamide induced diabetic rats revealed decreased malondialdehyde (MDA) and increased reduced glutathione (GSH). Thus the investigation results that oil of seeds of A hypogaeahave significant antihyperglycemic and antioxidant activity. Key words: Seeds, Streptozotocin, Essential oil, MDA.
Highlights
Nowadays, herbal remedies have become the popular source of medicines due to lesser adverse reactions (Kumar et al, 2012) and various other reasons
Diabetes in India in 2007 and this number is predicted to rise to almost 70 million people by 2025 according to Diabetes Atlas published by the International Diabetes Federation (IDF) (Kumar et al, 2012)
The blood glucose level rose to a maximum in 60 min after glucose loading
Summary
Herbal remedies have become the popular source of medicines due to lesser adverse reactions (Kumar et al, 2012) and various other reasons. Peanut (Arachis hypogaea L.) is one of the world’s most important legumes which is grown primarily for its high quality edible oil and protein. It is an important legume Africa (SA) (Reddy et al, 2003). Diabetes is growing with a high speed in India and has become a capital of the world which is affecting all age groups of people (Mohan et al, 2007). There were an estimated 40 million persons with diabetes in India in 2007 and this number is predicted to rise to almost 70 million people by 2025 according to Diabetes Atlas published by the International Diabetes Federation (IDF) (Kumar et al, 2012). The country with the largest number of diabetic people will be India by 2030
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