Abstract
A 21-year-old male presented to us with delayed development of secondary sexual characteristics. Based on examination and investigations, a diagnosis of idiopathic hypogonadotropic hypogonadism was made and the patient was started on testosterone therapy. After around a year of therapy the patient had an increase in bilateral testicular volume with increased serum luteinizing hormone (LH) values. The patient was advised to stop treatment. On follow-up there was persistence of increase in LH values with maintenance of normal serum testosterone values. Thus the case highlights the importance of regular follow-up in cases of idiopathic hypogonadotropic hypogonadism to watch for reversal. Key words: Puberty, hypogonadism, reversal.
Highlights
Idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by secondary hypogonadism frequently associated with anosmia (Fraietta et al, 2013)
We present a similar case of a male patient on testosterone therapy with reversal of IHH
The above case is an example of reversal of Idiopathic hypogonadotropic hypogonadism triggered by administration of testosterone
Summary
Idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by secondary hypogonadism frequently associated with anosmia (Fraietta et al, 2013). There was no family history of delayed puberty on examination, the patient was found to have a height above the 75th centile (171.5 cm), which was well above his mid parental height (160 cm) His arm-span was 177 cm and his upper segment to lower segment ratio was 0.87. His stretched penile length was 4 cm and his right and left testicular volumes were 3 and 4 cc respectively. In December, 2015 the patient had come to us for follow up On examination, his right and left testicular volumes were 8 and 10 cc respectively. His right and left testicular volumes were 8 and 10 cc respectively His basal 8:00 AM serum testosterone was 314.08 ng/dl. The patient was advised for follow-up after 3 months
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