English

Abstract

Objectives: To compare the efficacy of Magnetic resonance imaging andMammography for Breast-Cancer Screening in high risk Women with a Familial or GeneticPredisposition. Study Design: Cross-sectional study. Setting: Department of Radiology AlliedHospital, Faisalabad. Duration: From January 2012 to December 2014, Sample size: 299.Methods: A total of 299 females at high risk of breast cancer were included in this study andthey underwent screening rounds of Mammogram and contrast enhanced dynamic breastMRI once a year with independent readings. Both the imaging modalities were interpreted byexperience radiologist and all the images were categorized using Breast Imaging Reportingand Data System. In each patient, histopathology results were considered the standard criteriafor the calculation of the sensitivity, specificity for both Mammogram and Breast MRI lesions.Results: Mean age of the patients was 46.69±11.86 years. Mammography revealed 11 (3.68%)true positive breast lesions, 22 (7.36%) false positive lesion, 247 (82.61%) true negative and19 (6.35%) false negative lesions yielding the sensitivity of 36.67% and diagnostic accuracy of86.3%. Dynamic breast MRI revealed 28 (9.36%) true positive breast lesions with 5 (1.67%) falsepositive, 264 (88.29%) true negative and 2 (0.67%) false negative lesions yielding sensitivity of93.3%,specificity of 98.14%,PPV=84.85%,NPV=99.25% and diagnostic accuracy of 97.66%.MRI breast was significantly more sensitive (93.3 vs. 36.67%) and accurate (97.66 vs. 86.3%)than mammography. Conclusion: MRI is more sensitive than mammography in detectingtumors in women with an inherited susceptibility to breast cancer.