English

Abstract

AIM AND OBJECTIVES: To establish the prevalence and association of hypothyroidism in women affected with unexplained recurrent miscarriages. MATERIAL AND METHODS: This is an Observational case control study conducted in Obstetrics and Gynecology Department of NIMS Medical College and Hospital, Jaipur (Rajasthan); between July 2011 to June 2012.One hundred nonpregnant women with history of recurrent pregnancy losses were included in study group and one hundred non-pregnant women of similar age group with at least one successful pregnancy outcome were taken as control. All women who had known Thyroid disorder, diabetes, collagen and heart disease, were excluded from study. Detailed history, thorough physical examination was done and subjected to the quantitative estimation of triiodothyronine {T3}, Thyroxin {T4} and TSH hormone by CLIA method. RESULT: In the study 63% women experienced two or more pregnancy loss while 37% presented with three or more pregnancy losses. Total 7 patients were reported to have hypothyroidism out of which 3 were observed with subclinical hypothyroidism while 4 were detected overt hypothyroidism. In Control group 2 patient of subclinical hypothyroidism were detected. CONCLUSION: Prevalence of Hypothyroidism was 7 % and it has a statistically significant relationship with recurrent pregnancy losses in <20 weeks of gestation. Screening for thyroid dysfunction should be done early in pregnancy. Looking at the high percentage of abnormal TSH in pregnancies; universal screening should be considered as impaired thyroid function may predispose to miscarriage.