Abstract
The study aims to evaluate the effect of Tribulus terrestris and Andrographis paniculata on body weight, blood glucose, lipid profile and renal protective capability in alloxan induced type-1 diabetic mice. Six groups of five male Swiss Albino mice each, at four weeks of age were used in this experiment. Group-X were fed saline water and Group-Y with combined herbal formulation at a high dose (1 g/kg bwt) to asses toxicity .The remaining four groups were designated into healthy control, diabetic control , diabetic + Amaryl® 800 µg/kg , Diabetic + Formulation 200 mg/kg bwt .The combined formulation improved body weight loss and lowered blood glucose levels significantly (P<0.001) compared to diabetic control group after 8 weeks of treatment. The total cholesterol and plasma triglyceride were decreased at a significant level (P<0.01) compared to diabetic control. However, High density lipoproteins (HDL) and Low density lipoproteins (LDL) levels remained unchanged by combined formulation compared to diabetic control. The combined formulation also lowered the plasma creatinine levels in the formulation treated group compared to diabetic control. Histo-pathological evaluation revealed that combined formulation partially improved renal glomerular sclerosis and hypertrophy, tubular damage and pancreatic β-cells damage. The combined herbal formulation may have antidiabetic and renal protective capability in alloxan induced type-1 diabetic mice. Key words: Tribulus terrestris, Andrographis paniculata, blood glucose, lipid profile, renal injury, anitdiabetic effects.  
Highlights
Diabetes is a heterogeneous metabolic disorder characterized by altered carbohydrate, lipid and protein metabolism which causes hyperglycemia resulting from insufficient insulin secretion, insulin action or both (Mutalik et al, 2003; Joseph and Jini, 2011)
Group-X were fed saline water and Group-Y with combined herbal formulation at a high dose (1 g/kg bwt) to asses toxicity .The remaining four groups were designated into healthy control, diabetic control, diabetic + Amaryl® 800 μg/kg, Diabetic + Formulation 200 mg/kg bwt .The combined formulation improved body weight loss and lowered blood glucose levels significantly (P
This data from study-1 suggests that even in high dose herbal combination formulation have no significant effect on body weight and blood glucose level in healthy mice (Figure 1)
Summary
Diabetes is a heterogeneous metabolic disorder characterized by altered carbohydrate, lipid and protein metabolism which causes hyperglycemia resulting from insufficient insulin secretion, insulin action or both (Mutalik et al, 2003; Joseph and Jini, 2011). With an estimated 371 million affected adult people worldwide, diabetes mellitus is one of the most widespread diseases that caused 4.8 million deaths in 2012 (IDF, 2013). The most prevalent form globally is the non insulin dependent diabetes mellitus (NIDDM type-2) which is associated.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
