Abstract
This study determined the haemolytic, haemagglutinating and antibiotic susceptibility activities of Plesiomonas shigelloides isolated from stool samples of patients attending different health centers in the Venda region of South Africa. P.shigelloides was isolated and identified using the API 20E, API 20NE systems. Antibiotic susceptibility profiles of the isolates were determined using the disc diffusion method and analyzed according to NCCLS standards. The hemolytic and hemagglutination activities of the isolates on human, sheep, pig and chicken red blood cells were determined using the plate and slide methods. A total of 89 (13%) P. shigelloide were isolated from 660 samples. The hemolytic activities of the isolates were variable with no heamolysis on sheep red cells. 33 (37%) of isolates were beta lactamase producers. There was a high level of resistance to the penicilllins with 100% resistance to Penicillin G, Amoxicillin and Ampicillin. This study has demonstrated multiple resistance to different antibiotics and production of beta lactamase. Most of the isolates showed evidence of pathogenicity as demonstrated by hemolytic and haemagglutinating activities.
Highlights
Plesiomonas shigelloides is gram-negative rod which is found in freshwater, freshwater fish, shellfish and different types of animals such as cattle, goats, swine, cats, dogs, monkeys, vultures, snakes, and toads
Inspite of the clinical significance of P. shigelloides, little is known about the genetic landscape, updated antibiograms, structure of the population and extent of infections caused by the organism
We report on possible considerations of pathogenicity and antibiogram profiles of isolates as a prelude to an account of the genetic landscape of P. shigelloides in the Venda region of South
Summary
Plesiomonas shigelloides is gram-negative rod which is found in freshwater, freshwater fish, shellfish and different types of animals such as cattle, goats, swine, cats, dogs, monkeys, vultures, snakes, and toads. Inspite of the clinical significance of P. shigelloides, little is known about the genetic landscape, updated antibiograms, structure of the population and extent of infections caused by the organism As a prelude to unraveling the genetic diversity, which will impact on epidemiological control, a study on the prevalence, virulence potential and antibiograms of the organism is critical in order to gauge the extent of the problem, ascertain pathogenic factors and antibiograms of isolates for clinicoepidemiological relevance and for empiric management of infections requiring antibiotics.
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