Abstract
Caatinga biome features species with high therapeutic potential such as Aroeira do Sertao (Myracrodruon urundeuva Allemao) which has long history in folk medicine. This study aimed to chemically characterize the secondary metabolites of hydroethanolic extract and hexane, chloroform, acetate, hydroethanolic fractions from Myracrodruon urundeuva (Allemao) possibly responsible antioxidant and antimicrobial activity, besides to evaluate the inotropic effect of crude extract in the left atrium of Cavia porcellus. Phytochemical composition was evaluated by spectrophotometry and high-performance liquid chromatography (HPLC). Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hidrazyl (DPPH•) scavenging and reactive substances to thiobarbituric acid methods. Inotropic effect was evaluated using the isolated organ model. Data were expressed as mean ± SEM and differences determined by ANOVA followed by Tukey test. Phytochemical screening and the HPLC confirmed the presence of flavonoids, terpenes, tannins. Acetate and Hydroethanolic extract showed inhibition of DPPH values of 81.56 and 93.28% respectively. On the other hand, TBARS reduced in extract were 64.13% in a concentration of 150 µg/mL. Hydroethanolic extract and acetate fraction with concentrations of 50 and 100 mg/mL showed inhibition zones between 11.00 and 20.50 mm suggesting antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae bacteria and Candida albicans. The isolated atrium model demonstrated that the extract acts non-competitively antagonizing muscle calcium currents, decreasing the force of contraction by about 60%. Flavonoids, terpenes and tannins are responsible for M. urundeuva (Allemao) biological effects. Key words: Myracrondruon urundeuva, chemical composition, antioxidant activity, antimicrobial activity, inotropic effect.
Highlights
The ethnobotanical study allows rescuing the popular knowledge, supporting research in related fields, while contributing to prioritize species in need of conservation since these have a therapeutic and economic potential that are aimed especially by the pharmaceutical industry which prospects new products using these species.In this context, the studies about microbial action of natural compounds are of utmost importance for the rise of bacterial strains resistant to several types of antibiotics is increasing, and the occurrence of side effects such as: Diarrhea, vomiting and dental stains common by the use of reference drugs (Menezes et al, 2004).A number of human diseases are caused by oxidative stress due to imbalance between the formation and neutralization of pro-oxidants
Phytochemical composition was evaluated by spectrophotometry and highperformance liquid chromatography (HPLC)
Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hidrazyl (DPPH) scavenging and reactive substances to thiobarbituric acid methods
Summary
The ethnobotanical study allows rescuing the popular knowledge, supporting research in related fields, while contributing to prioritize species in need of conservation since these have a therapeutic and economic potential that are aimed especially by the pharmaceutical industry which prospects new products using these species.In this context, the studies about microbial action of natural compounds are of utmost importance for the rise of bacterial strains resistant to several types of antibiotics is increasing, and the occurrence of side effects such as: Diarrhea, vomiting and dental stains common by the use of reference drugs (Menezes et al, 2004).A number of human diseases are caused by oxidative stress due to imbalance between the formation and neutralization of pro-oxidants. The ethnobotanical study allows rescuing the popular knowledge, supporting research in related fields, while contributing to prioritize species in need of conservation since these have a therapeutic and economic potential that are aimed especially by the pharmaceutical industry which prospects new products using these species In this context, the studies about microbial action of natural compounds are of utmost importance for the rise of bacterial strains resistant to several types of antibiotics is increasing, and the occurrence of side effects such as: Diarrhea, vomiting and dental stains common by the use of reference drugs (Menezes et al, 2004). Oxidation reactions may produce free radicals, which play a vital role in damaging various cellular macromolecules. This damage results into various diseases like arthritis, diabetes, asthma, liver damage, atherosclerosis, inflammation and carcinogenesis (Mushtaq et al, 2017). The neutralization of free radicals produced in the organism is related to diseases like cancer, diabetes, Alzheimer's and Parkinson's, as well as heart problems (Paixão et al, 2013) according to the World Health Organization, “cardiovascular diseases will be in 2015, main causes of death in developed and developing countries” (Oliveira et al, 2009)
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