English

Abstract

BACKGROUND Acute myocardial infarction is a form of ischemic heart disease in which there is an inadequate supply of blood and oxygen to a portion of the myocardium. It typically occurs when there is an imbalance between myocardial oxygen supply & demand. In this study, we wanted to determine the prognostic significance of serum uric acid concentration in acute myocardial infarction. METHODS This is a cross-sectional comparative study conducted among 100 acute myocardial infarction patients admitted at VIMSAR, Burla during the study period from November 2017 to October 2019 and also 50 age and gender-matched healthy controls person who presented to the hospital OPD with other reasons. All patients were diagnosed with ST-segment elevation acute myocardial infarction based on clinical history, examination, ECG changes, and biochemical markers. Detailed general examination and detailed systemic examination of cardiovascular, neuromuscular, gastrointestinal, respiratory & genitourinary system were done with routine tests: Hb%, TLC, DC, ESR, S. Urea, S. Creatinine, Fasting/RBS, Blood Sugar, Urine, R/M, Serum uric acid, Troponin I & CPK-MB and ECG in all leads. Evaluation of patient was done to access the Killip class on the day of admission and once among 50 age and gender-matched healthy controls. RESULTS The mean serum uric acid level was higher in patients with acute myocardial infarction than the healthy controls. There was no significant difference in the mean serum uric acid level between males & females and the mean serum uric acid level between diabetic & non-diabetic patients. Patients in the higher Killip class had higher serum uric acid levels. All patients who died in the study were in the higher Killip class and had higher S.uric acid levels. CONCLUSIONS A combination of Killip class & serum uric acid level after acute myocardial infarction is a good predictor of mortality. KEY WORDS Myocardial Infarction, ST Segment Elevation, CPK-MB, Serum Uric Acid.