Abstract
A series of several diazenyl schiff base molecules were designed and synthesized through azo coupling of diazotised primary amines with the novel synthesized schiff base ligand (E)-N-((2-chloroquinolin-3-yl)methylene)-4-phenylthiazol-2-amine. All the synthesized molecules have been characterized by different spectral techniques for their structural confirmation. The results of in vitro antioxidant activity of the molecules by 2,2-diphenyl-1- picryl hydrazyl (DPPH) assay method revealed that the molecules (NZ)-N-(((4-chlorophenyl) diazenyl) (2-chloroquinolin-3-yl) methylene) -4- phenylthiazol -2-amine (5A) and 4-(((Z)-(2-chloroquinolin-3-yl)(4-phenylthiazol-2-ylimino)methyl)diazenyl)phenol (5E) have shown potential free radical scavenging activity. Key words: Schiff base, diazenyl, spectral, antioxidant.
Highlights
Oxidative stress is an imbalance between the reactive oxygen species (ROS) and the detoxifying biological process
When our endogenous supply of the antioxidants are insufficient, the level of free radicals gets increased in our body causing internal cellular damage (Dubey and Batra, 2009)
The spectroscopic analysis of the synthesized molecules were performed by Fourier Transform/ InfraRed (FT/IR) (JASCO FT/IR 4100 Spectrophotometer) using KBr pellets, Liquid chromatography-mass spectrometry (LC-MS) (Shimadzu-Mass spectrophotometer) and 1H NMR (Bruker1HNMR 400 MHz) using tetramethylsilane as an internal standard
Summary
Oxidative stress is an imbalance between the reactive oxygen species (ROS) and the detoxifying biological process. As a strong oxidizing agent, it facilitates most of the metabolic processes in the body and in due process it generates free radicals. When our endogenous supply of the antioxidants are insufficient, the level of free radicals gets increased in our body causing internal cellular damage (Dubey and Batra, 2009). Free radicals are generated by the external sources of environmental pollutants such as toxic metals, cigarette smoke and pesticides, which damage our body (Aseervatham et al, 2013). Antioxidants are capable of slowing and preventing the oxidation to build a control over the free radicals generation.
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