Abstract
The present experimental work was conducted to elucidate the gross and histopathological studies in broiler chicks when treated with Diclofenac sodium, Ibuprofen and Nimesulide. For this study, 120 apparently healthy broiler chicks of either sexes were randomly divided into 10 groups comprising of 10 birds in 9 groups and 30 birds in control group. The broilers of Diclofenac groups were given 10, 20 and 30 mg/kg body weight of Diclofenac sodium for 5 days. Similarly the broilers of Ibuprofen groups were administered 15, 30 and 45 mg/kg body weight of Ibuprofen with feed for 5 days. On the other hand the birds of Nimesulide groups were also given 10, 20 and 30 mg/kg Nimesulide for 5 days. The Nimesuldie groups did not show any lesions of gout but the birds intoxicated with Diclofenac and Ibuprofen revealed mild to moderate lesions of gout characterized by deposition of white chalky urates on the organ surface. Key words: Diclofenac, Ibuprofen, Nimesulide, broiler, toxicity.
Highlights
The present experimental work was conducted to elucidate the gross and histopathological studies in broiler chicks when treated with Diclofenac sodium, Ibuprofen and Nimesulide
The Nimesuldie groups did not show any lesions of gout but the birds intoxicated with Diclofenac and Ibuprofen revealed mild to moderate lesions of gout characterized by deposition of white chalky urates on the organ surface
Non-steroidal anti-inflammatory drugs (NSAlDs) are commonly used as anti-inflammatory, antipyretic and analgesic. They produce their action by inhibiting the activities of cyclooxygenase enzymes (COX-1 and COX2) which mediates the production of prostaglandins from arachidonic acid
Summary
Gross and histopathological studies of Diclofenac, Ibuprofen and Nimesulide induced toxicity in broilers. The present experimental work was conducted to elucidate the gross and histopathological studies in broiler chicks when treated with Diclofenac sodium, Ibuprofen and Nimesulide. The broilers of Diclofenac groups were given 10, 20 and 30 mg/kg body weight of Diclofenac sodium for 5 days. The broilers of Ibuprofen groups were administered 15, 30 and 45 mg/kg body weight of Ibuprofen with feed for 5 days. On the other hand the birds of Nimesulide groups were given 10, 20 and 30 mg/kg Nimesulide for 5 days. The Nimesuldie groups did not show any lesions of gout but the birds intoxicated with Diclofenac and Ibuprofen revealed mild to moderate lesions of gout characterized by deposition of white chalky urates on the organ surface
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Toxicology and Environmental Health Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
