Abstract
An antimicrobial compound, highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin. The minimal inhibitory concentrations (MICs) of manumycin against 8 different strains of methicillin-resistant Staphylococcus aureus (MRSA) were ranged 2 to 32 μg/ml. Similarly, MICs of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains. Compared to vancomycin, manumycin provided slightly weaker activity against MRSA strains but stronger activity against 4 VRE strains. This is the first report of antagonistic effect of manumycin against MDR pathogens. Keywords : Manumycin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) African Journal of Biotechnology Vol. 12(17), pp. 2249-2253
Highlights
Manumycin is a group of small and discrete class of antibiotics which consist of almost a dozen secondary metabolites produced exclusively by Streptomyces (Sattler et al, 1998)
Highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin
minimal inhibitory concentrations (MICs) of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains
Summary
Manumycin is a group of small and discrete class of antibiotics which consist of almost a dozen secondary metabolites produced exclusively by Streptomyces (Sattler et al, 1998). Manumycin was first reported by Buzzetti and coworkers in 1963. Its chemical structure has two unsaturated carbon chains, so called m-C7N and C5N unit, which are linked in meta-fashion to unique multifunctional six-membered ring. Manumycin-type compounds derived from the m-C7N unit vary in its stereochemistry and the nature of the oxygen substituent.
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