Abstract
Portulaca oleracea L. (POL) has been used as one of the traditional oriental medicines to treat bacteria, virus, antherasis, caducity, diabetes and for enhancing immunity. This study aims at revealing effects of POL on alloxan-induced diabetic rats and its mechanisms. According to thin layer chromatography assay, the main compounds of POL included organic acid,flavonoids, alkaloids, terpene ansteroid, hydroxybenzene, saponin and polysaccharide. The rats were divided into four groups: normal control (NC), diabetes control (DC), diabetes + POL high dose (400 mg/kg), diabetes + POLlow dose (200 mg/kg). The diabetic rats were administrated with POL or dH2Odaily for 28 days. The POL treatment resulted in significant decreases of fasting blood glucose, total cholesterol and triglycerides. POL also showed a tendency of improvement body weight gain on diabetic rats. Furthermore, the DC group had low serum insulin level comparing with that of NC group, at the same time,the insulin levels were dose-dependently raised in the POL-treated groups than that of DC group. According to single cell gel electrophoresis and LD50 analysis, POL was proved to be nontoxic to the animals. The results indicate that POL would alleviate the blood glucose and lipid rising associated with diabetes, and improve the abnormal glucose metabolism and increase insulin secretion byrestoring the impaired pancrease β cells in alloxan-induced diabetic rats, which suggest that POL has the hypoglycemic potential and could be useful on the diabetes therapy. Key words: Portulaca oleracea L., diabetes, hypoglycemia, hypolipidemia, insulin.
Highlights
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action
There was no significant difference at 0 min among the diabetes control (DC) and Portulaca oleracea L. (POL) treated groups (Figure 1)
P. oleracea L. has been used as a traditional medicine for many years in China, owing to its therapeutical properties of anti-bacteria, anti-virus, anti-antherasis, anti-caducity, and enhancing immunity
Summary
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action. (POL) (Chinese name Ma-ChiXian) is widely used in China as an edible plant, and as a traditional Chinese herbal medicine for alleviating pain and swelling. It has the abilities of defending bacteria, virus, antherasis, caducity, diabetes, and for enhancing immunity (Jian et al, 1986), but the mechanism of action and its compounds have not been clarified. We analyzed the compounds of POL extract and investigated its hypoglycemic effects. Activities of the extract were determined by comparing the changes in blood glucose, body weight, serum triglyceride (TG) and total cholesterol (TC) levels in alloxan-induced diabetic rats. The serum insulin levels in four groups were determined by Elisa, and the toxicity of POL was assayed in single-cell gel electrophoresis and LD50 experiments
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