Abstract
Polygonatum odoratum is an important herbal medicine that is used in folk medicine for the treatment of various elements and its components are reported to have various biological effects. This study was conducted to evaluate the effects of topical application of ethanol leaf extract of this plant on the rate of wound healing closure and histology of healed wound. Four groups of male Sprague Dawley rats, all were experimentally wound in the posterior neck area. The animal groups were topically treated respectively with 0.4 ml of each vehicle (gum acacia), Intrasite gel, 100 and 200 mg/ml of ethanol leaf extract. Macroscopically, wound dressed with leaf extracts and Intrasite gel-treated group significantly healed earlier than those treated with vehicle, and the rate of wound healing was significantly accelerated by topical application of 200 mg/kg leaf extract. Histological analysis of healed wounds dresses with leaf extracts showed comparatively less scar width at wound closure and healed wound contained less inflammatory cells and more collagen with angiogenesis as compared to wounds dressed with vehicle. In conclusion, wounds dressed with leaf extracts significantly enhanced the acceleration of wound healing enclosure in rats. Key words: Polygonatum odoratum leaf, ethanol extract, wound healing, histology.
Highlights
Normal wound healing response begins the moment the tissue is injured
Wound contracture is a process that occurs throughout the healing process, commencing in the fibroblastic stage whereby the area of the wound undergoes shrinkage
Topical application of P. odoratum significantly accelerated the rate of wound healing, and histology, healed wound contain comparatively less inflammatory, more collagen and angiogenesis
Summary
Normal wound healing response begins the moment the tissue is injured. Wound healing is the process of repair that follows injury to the skin and other soft tissues (Nguyen et al, 2009). Proper healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin (Begum and Nath, 2000). Healing is a complex and intricate process initiated in response to an injury that restores the function and integrity of damaged tissues (Govindarajan et al, 2007). Wound healing involves continuous cell-cell and cell-matrix interactions that allow the process to proceed in three overlapping phases, inflammation, cellular proliferation and remodeling (Martin, 1996; Souba and Wilmore, 1999). Several plants and herbs have been used experimentally to treat skin disorders, including wound injuries, in traditional medicine (Karodi et al, 2009; Csupor et al, 2010)
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