English

Abstract

OBJECTIVE: The therapeutic role of Xanthinolnicotinate was studied in 120 patients with inoperable peripheral vascular disease who completed a 4 weeks regimen of intravenous continuous infusion. METHODS: This is a prospective study of 120 patients with inoperable progressive peripheral obliterative vascular disease admitted in the Department of Cardiothoracic & Vascular Surgery, Sawai Man Singh Medical College, Jaipur, Rajasthan. The clinical response like limb temperature, peripheral pulses, skin colour and capillary filling time along with patient response on relief of rest pain and claudication pain are recorded in a simple manner. RESULTS: This response is observed during and just after follow up. Long term usage is still questionable. Out of the 120 patients, 117 cases (97.5%) had claudication pain which after treatment, 106 cases (87.9%) had some relief and sense of well-being. 74 cases (61.7%) presented with rest pain out of which 60 cases (49.8%) got relief and had decreased analgesic usage. Rise in limb temperature with regained pulse and increased capillary filling was clinically observed in 27 cases (22.4%). There was a case of reappearance of pulsation in an acute case where the blockage was post intra-arterial annulation. Reversion of pre-gangrenous cyanotic changes was found in 15 cases (12.5%) but out of which 3 cases ultimately went to amputation on follow up. CONCLUSION: Overall Xanthinolnicotinate has been found a useful drug for peripheral vascular disease patients in whom vascular surgery is not indicated or contraindicated.