Abstract
This study aimed to evaluate the clinical effects of YiShenTongMai decoction working with conventional Western drugs in patients with unstable angina complicated with glucose metabolism disorder. Seventy-six patients with unstable angina complicated with glucose metabolism disorder were randomly divided into two groups: 37 cases were allotted to the control group and were treated with conventional Western medicine; 39 cases were allotted to the experimental group treated with conventional Western medicine and YiShenTongMai decoction (Gold Theragran 20 g, Chinese yam 30 g, Milkvetch root 15 g, Bombyx mori 10 g, Allii macrostemi bulbus 10 g, Cassiac torae 30 g, huai Achyranthis radix 15 g, notoginseng powder 3 g, Pheretima asiatica 15g, Chinese hawthorn 10 g and water 370 ml). The effect of treatment was studied on the indices of electrocardiogram, traditional Chinese medicine (TCM) syndromes, fibrinogen (FIB), C-reactive protein (CRP) levels, standard deviation of Normal-Normal (SDNN), and left ventricular diastolic function (E/A) ratio. There was a significant difference with regards to clinical manifestation improvement in angina control between the experimental group and the control group (94.9% versus 75.7%, P < 0.05), as well as in the electrocardiogram profile (84.6% versus 59.5%, P < 0.05) and syndrome integral (94.9% versus 70.3%, P < 0.05). FIB and CRP decreased while SDNN and E/A increased in both groups but was much higher in the experimental group (P < 0.05). The curative effect of combined YiShenTongMai decoction and Western medicine was better than Western medicine alone in patients with unstable angina complicated with glucose metabolism disorder patients. Key words: Unstable angina, glucose metabolism disorder, YiShenTongMai decoction.
Highlights
Coronary heart disease (CHD) and diabetes (DM) are both serious health problems in China as well as all around the world
This study aimed to evaluate the clinical effects of YiShenTongMai decoction working with conventional Western drugs in patients with unstable angina complicated with glucose metabolism disorder
Seventy-six patients with unstable angina complicated with glucose metabolism disorder were randomly divided into two groups: 37 cases were allotted to the control group and were treated with conventional Western medicine; 39 cases were allotted to the experimental group treated with conventional Western medicine and YiShenTongMai decoction (Gold Theragran 20 g, Chinese yam 30 g, Milkvetch root 15 g, Bombyx mori 10 g, Allii macrostemi bulbus 10 g, Cassiac torae 30 g, huai Achyranthis radix 15 g, notoginseng powder 3 g, Pheretima asiatica 15g, Chinese hawthorn 10 g and water 370 ml)
Summary
Coronary heart disease (CHD) and diabetes (DM) are both serious health problems in China as well as all around the world. From the 1990s, CHD has become the primary cause of death, and has increased gradually. For DM, there were 194 million patients in 2003, and the number will reach 333 million in 2025 with a higher rate of increase in developing countries than developed countries. DM is an important risk factor for CHD; in DM patients, the ratio of attack by CHD was much higher (Carneiro, 2004) and the clinical manifestations were much more serious (Alexander et al, 2003). Eighty percent of DM patients died of cardiovascular complications, and 75% died of CHD (Gillum et al, 2000); this ratio was 2 to 4 times higher than that of patients without DM (Juutilainen et al, 2005). It was found that the impaired glucose regulation (IGR) of early DM, including
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