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Abstract
Ameloblastomas are a class of odontogenic tumors, which arise from developmental remnants in the oral tissue. Although the cellular and molecular mechanisms resulting in development of ameloblastoma are poorly understood, it is generally accepted that they exhibit an odontogenic source and originate from epithelial cells associated with tooth development. The epithelial sources in the oral tissue that can cause ameloblastomas include enamel organ, reduced enamel epithelium, rests of Malassez, and rests of Serres. These remnants originate from the stomodeal ectoderm, which give rise to the oral epithelium that initiate and guide tooth development as the embryo develops. It is of great clinical value to understand the developmental origin of these epithelial components and their histology, since the ameloblastomas display histopathological similarities to their structures.
Highlights
Ameloblastomas are locally invasive and slowly growing odontogenic tumors that constitute about 1% of head and neck neoplasms
The initiation of tooth development starts with thickening of the oral epithelium, which subsequently extends into the underlying ectomesenchyme as a dental lamina[6]
As amelobastomas are characterized by a slow-growth, their development may initiate in childhood. The similarities between these odontogenic tumors and the tissues found under tooth development in the childhood make it difficult to distinguish them histologically
Summary
Ameloblastomas are locally invasive and slowly growing odontogenic tumors that constitute about 1% of head and neck neoplasms. Another typical histological characteristic is the budding of tumor cells from neoplastic foci in a pattern similar to that present in developing tooth germ. The mammalian tooth develops from cells originating from stomodeal ectoderm, which forms the epithelium, and interacts with the underlying neural-crest derived ectomesenchyme[6]. The initiation of tooth development starts with thickening of the oral epithelium, which subsequently extends into the underlying ectomesenchyme as a dental lamina[6].
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