Abstract
The alcohol-extraction-water-precipitation fraction of Swertia mussotii Franch. (SME-d) had been proved to be hepatoprotective without toxicity in previous report. In this article, high performance liquid chromatography (HPLC), rat experiment and P450 model tests were employed for studying the pharmacology characteristics of SME-d. The results showed that the contents of sweroside, swertiamarin, mangiferin, gentiopicroside, and isoorientin were 0.24, 3.96, 12.30, 13.53, 16.85 mg/g in SME-d, respectively. SME-d could reduce the CCl4-induced exaltation of alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), total bile acid (TBA) significantly in rat, and the protective activity showed dose-dependent in 0.9 and 1.8 g/kg body weight (BW). The hepatoprotective activity of SME-d was different to positive drug bifendate, which only did on ALT value significantly. Bifendate could inhibit 66.17 ± 2.12% of CYP3A4 activity, while SME-d showed 99.0 ± 0.267% reductions on CYP1A2. The different medicinal characteristics of SME-d to bifendate, which are used widely to cure hepatitis in china, can give more choices for hepatitis. Key words: Swertia mussotii Franch, the alcohol-extraction-water-precipitation fraction, pharmacology characteristic, hepatoprotective activity.
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