Abstract
The aim of this study was to test the antimicrobial activities of crude chloroform, hexane, ethyl acetate and ethanol extracts of the leaves Glycyrrhiza glabra (GG) and Fagonia arabica (FA) against bacteria (Escherichia coli, Staphylococcus epidermidis,Staphylococcus aureus and Bacillus subtilis). Antimicrobial properties of G. glabra and F. arabica were tested using Agar well diffusion method and Agar disc diffusion method. Streptomycine was used as standard drug with significant activity values, that is, 23 mm against E. coli, 36 mm against S. epidermidis, 34 mm against S. aureus and 26 mm againstB. subtilis. Analysis of data showed that the crude extract of G. glabra and F. arabica in dichloromethane exhibited superior activity against E. coli and S. epidermidis. Results were compared concomitantly to standard drugs; streptomycine. Phytochemical screening of G. glabra and F. arabica showed the presence of terpenoids, saponins, flavonoids, alkaloids, tannins, glycosides and reducing sugar components. Based on the current conclusion, it can be accomplished that these plants has antimicrobial activity, which is as potent as standard antimicrobial drugs against definite microorganisms. Key words: Glycyrrhiza glabra and Fagonia arabica, antimicrobial, phytochemical screening, medicinal plants.
Highlights
IntroductionDependency and sustainability of man and animal life has been revolving around plants through their uses as food, clothing and shelter, and plants have been used to control diseases; the use of plants as medicines is an ancient and reliable practice (Arshad and Rao, 2001)
Life and diseases go together where there is life, diseases are bound to exist
Findings of cup-plate diffusion method for ethanolic extracts of G. glabra and F. arabica are shown in Figures 1 and 2
Summary
Dependency and sustainability of man and animal life has been revolving around plants through their uses as food, clothing and shelter, and plants have been used to control diseases; the use of plants as medicines is an ancient and reliable practice (Arshad and Rao, 2001). It is reported by WHO that more than 80% of the world’s population depends on traditional medicine for the treatment of their illnesses (Norman et al, 1985). Owing to the development of drug resistive strains in human pathogens against commonly used antibiotics, it is necessary to discover new antimicrobial substances from plants and other sources. The constituent is 50 times sweeter than sugar, and widely used as a sweetening agent in food industry (Acharya, 1993).
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