Abstract

The substrate of kinases linked to T and B-cell receptors, such as Lck and Lyn kinases, was first identified in haematopoietic lineage cell-specific protein 1 (HS1). HS1 is a multidomain protein that helps branched actin polymerize by activating the Arp2/3 complex. It's the immune system's version of cortactin, a ubiquitous protein linked to cell migration, endocytosis, and bacterial pathogen invasion of host cells.

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