Abstract
The current study was directed on methanolic extract of Neolamarckia cadamba fruits, belonging to the family Rubiaceae, to reveal the possible phytochemicals existence and also to evaluate the membrane stabilizing, anthelmintic, antioxidant properties. To estimate the membrane stabilizing activity, both heat and hypotonic solution induced haemolysis techniques were used. The anthelmintic test was conducted on earthworm Pheritima phosthuma using five different concentrations (10, 20, 40, 60, 80 mg/ml) of the extract and albendazole as standard drug (concentration 10 mg/ml). To investigate antioxidant property, two potential tests namely total phenolic content determination and the 2,2-diphenylpicrylhydrazyl (DPPH) free radical scavenging assay were conducted. Phytochemical screening was carried out using different chemical group tests. The extract revealed good membrane stabilizing activity inhibiting both hypotonic solution and heat induced haemolysis in comparison to inhibition by standard acetyl salicylic acid. The methanolic extract showed potent anthelmintic activity at the highest concentration as it required less time for paralysis and death compared to the standard drug albendazole. The fruit extract showed potential antioxidant property. The analysis of phytochemicals reveals the presence of carbohydrate, phenol, phytosterol, protein and amino acid, terpene and glycoside. The results of the study showed that the plant extract has potential membrane stabilizing, antihelmintic, antioxidant activities along with the presence of significant phytochemicals. Key words: Neolamarckia cadamba, membrane stabilizing activity, anthelmintic activity, antioxidant, phytochemicals.
Highlights
Neolamarckia Cadamba (Roxb.) Bosser is a well-known evergreen tropical flowering plant of Bangladesh, locally called "Kadam", belonging to the Rubiaceae family
The results showed that the extracts were significantly (p
The results of our investigation showed that the extract at a concentration of 2 mg/ml readily protected the lysis on human erythrocyte membrane induced by hypotonic solution as well as heat induced solution compared to the standard acetyl salicylic acid (0.1 mg/ml)
Summary
Neolamarckia Cadamba (Roxb.) Bosser is a well-known evergreen tropical flowering plant of Bangladesh, locally called "Kadam", belonging to the Rubiaceae family. It is native to Bangladesh, Nepal, India, Myanmar, Sri Lanka, Philippines, Indonesia and Papua New Guinea (Uddin et al, 2013; Ganjewalaa et al, 2013). Time, different parts of this plant have been used as antidiuretic, anti-pyretic, in the treatment of anemia, tumor as well as for the improvement of semen quality (Ahmed et al, 2011; Umachigi et al, 2007). Some previous studies evidenced that the plant possesses antimicrobial, antioxidant, and wound healing (Umachigi et al, 2007) as well as anti-diarrheal properties (Alam et al, 2008). The plant is sometimes used in the treatment of various ailments like diabetes mellitus, inflammation, haemoptysis, cough, vomiting, ulcers and debility (Dubey et al, 2011). Its timber is used for making pulp and paper, boxes and furniture while its wood is used as fuel (Mishra, 2011)
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