Abstract
The present study evaluates anti-hyperlipidaemic and anti-atherogenic activities in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rat models. Chloroform, ethyl acetate and ethanol extracts of whole plant of Blepharis maderaspatensis were evaluated for their anti-hyperlipidaemic and anti-atherogenic activities using Triton WR-1339 induced hyperlipidaemic rats (acute study) and high cholesterol diet induced (chronic study) experimental models. Hyperlipideamia was developed by intraperitonial injection of Triton WR-1339 (200 mg/kg body weight) in acute study and feeding with cholesterol rich diet in chronic study. The animals were divided into various groups and intragastric administration of various extracts of B. maderaspatensis (100 mg/kg) body weight was given in both models. After the completion of the treatment, they were evaluated for serum total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), atherogenic index (AI), coronary risk index (CRI) and were compared with the rats treated with simvastatin (20 mg/kg) of the body weight. Pre-treatment of ethanol extracts of B. maderaspatensis significantly reduced the serum total cholesterol, triglycerides, LDL, VLDL, AI and CRI as comparable with simvastatin. Key words: Serum lipids, atherogenic index, cholesterol diet, coronary risk index, Triton WR-1339, Blepharis maderaspatensis, high cholesterol diet.
Highlights
Diseases of the cardiovascular system are the most common cause of death in many developed countries (Epstein, 1992)
In comparison with the normal control group (Group I), Triton WR-1339 is found to have a marked increase of plasma total cholesterol (TC) and triglyceride levels of Triton WR-1339 control group (Group 2) and 100 mg/kg of chloroform extract, ethyl acetate extract and ethanol extract treated (Groups 3, 4, 5 and 6) rats
Hypercholesterolemia, which modifies cholesterol metabolism, is widely recognized as a major risk factor leading to mortality
Summary
Diseases of the cardiovascular system are the most common cause of death in many developed countries (Epstein, 1992). It is established that hyperlipidaemia represents a major risk factor for the premature development of atherosclerosis and its cardiovascular complications. Metabolic and toxicological research is extensively involved in elucidating risk factors for hypercholesterolemia and its pathologic consequences which involve the cardiovascular system, the brain and other organs. Hypercholesterolemia is usually produced by dietary and/or genetic manipulations. Hypercholesterolemia occurs as a toxic response to certain synthetic detergents. A diet high in cholesterol content is a major environmental contributor to an unbalanced lipoprotein metabolism and is associated with an increased prevalence of atherosclerosis. Epidemiological, clinical, genetic and experimental studies indicate that high serum levels of low density lipoprotein (LDL) cholesterol are associated
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