Abstract
Respiratory diseases are responsible for significant morbidity and mortality in worldwide. One of most important respiratory disease is asthma, which the current treatment is based on use of β2‑agonists combined to inhaled corticosteroids. However, in recent years, many in vitro studies have attempted to validate the use of aromatic medicinal plants and its chemical compounds, such as monoterpenes, as potential therapeutically alternatives. In this work it was demonstrated that three different monoterpenes (carvacrol, citronellal and p-cymene) has relaxant effect in guinea-pig trachea, somehow showing different profile regarding epithelium presence, potency and efficacy. Key words: Monoterpenes, carvacrol, p-cymene, citronellal, guinea-pig trachea, relaxant effect.
Highlights
Respiratory diseases are responsible for significant morbidity and mortality in worldwide
The monoterpenes carvacrol, citronellal and p-cymene induced a relaxing effect in a concentration-dependent manner of the tracheal rings pre-contracted with carbachol
The other two monoterpenes showed no significant differences between their potential for being equipotent in relaxing the trachea
Summary
Respiratory diseases are responsible for significant morbidity and mortality in worldwide. Asthma and chronic obstructive pulmonary disease (COPD) are of the most common in the world (Ambrosino and Paggiaro, 2012). World Health Organization (WHO), 300 million people suffer from asthma and this number could reach 400 million by 2025, accounting for 200,000 deaths per year (Meetoo, 2008).
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