Abstract
Garlic is used widely in food and pharmaceutical preparations in India. The hypolipidemic, anti-atherosclerotic as well fibrinolytic properties of garlic sulphur compounds are known since long time. This principle sulphur compound present in garlic extract and garlic oil is Diallyldisulphide (DADS) an unsaturated aliphatic disulphide, which is thought to be mainly responsible for garlic beneficial effects. The present work was under taken to assess usefulness and toxic effects of the garlic extracts in high lipid diet (HLD) fed rats. It is evident from results that garlic aqueous extracts have hypolipidemic effects in plasma and fatty changes in liver in high lipid diet rats. These hypolipidemic effects of garlic aqueous extracts may be due to its principle sulfur compound DADS.
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