Abstract
Due to the resistance of some mosquitoes to pyrethroids insecticides, new synthetic compounds are of great interest for the development of new insecticides against vectors of tropical diseases, especially in the Amazon region. Our aim was to synthesize and evaluate the larvicidal potential of benzoyl thiosemicarbazone and its Ni(II) complex against larvae of Aedes aegypti and Anopheles darlingi . The compounds were synthesized from thiosemicarbazide according to the literature, and the larvicidal potential was evaluated in triplicate at concentrations of 7 to 500 µg/mL. Benzoyl thiosemicarbazone and its Ni(II) complex showed an LC50 of 42.09 and 42.28 µg/mL, respectively, against . Ae. aegypti larvae. For .An. darlingi larvae, the LC50 values of benzoyl thiosemicarbazone (4.77 µg/mL) were lower than its Ni(II) complex (7.33 µg/mL). Benzoyl thiosemicarbazone presented satisfactory results against the larvae, and due to the insecticidal potential of this substance, the development of new chemical insecticides may be possible. Key words: Benzoyl thiosemicarbazone, nickel (II), larvicidal activity; Aedes aegypti, Anopheles darlingi.
Highlights
Many pathogens can be transmitted to humans from infected mosquitoes such as Aedes aegypti (Linnaeus, 1762), a species responsible for the transmission of dengue fever, yellow fever, Chikungunya and Zika
We examined the larvicidal activity of benzoyl thiosemicarbazone and its nickel (II) complex in bioassays against A. aegypti and A. darlingi, for the control of tropical diseases in the Amazon
Our study addresses the process for obtaining the substance and its nickel complex as well as their larvicidal activity against vectors of dengue and malaria in the Amazon region not yet described in the literature
Summary
Many pathogens can be transmitted to humans from infected mosquitoes such as Aedes aegypti (Linnaeus, 1762), a species responsible for the transmission of dengue fever, yellow fever, Chikungunya and Zika. In Brazil, this vector is one of the main public health problems, since it is extremely urban, has high population growth rates and is difficult to control (Simon et al, 2008; Puccioni-Sohler et al, 2017). Anopheles darlingi (Root, 1926) is of great medical relevance, as it is the vector responsible for the transmission of Malaria in Brazil, where it is basically confined to the Amazon region.
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