Abstract
Omega-3 polyunsaturated fatty acids have been shown to decrease inflammatory markers such as TNF-α, IL-1ß and IL-6 levels. It has been shown that there is association between several markers of inflammation with cardiovascular disease which is the leading cause of death in the end stage of renal disease (ESRD) patients. So it may be useful to administer this supplement in renal transplant recipients. To investigate this possibility, we studied the effect of omega-3 on the occurrence of acute rejection. In this study, we assessed the effect of 6 months of dietary supplementation with 6 g/day of omega-3 fatty acids on Lipid profile (TG, HDL-C, and LDL-C) and serum concentration of TNF-a, IL-6 and hs-CRP in renal transplant recipients. Based on these data, omega-3 fatty acids supplementation does not cause a decrease in serum level of tested inflammatory biomarkers in renal transplant recipients but decreases total cholesterol level. Key words: Omega-3 fatty acids, renal transplantation, inflammatory biomarkers.
Highlights
In renal transplant recipients, acute rejection occurred after renal transplantation, and cytokines have an important role in immune response—in the maturation of lymphocytes and in their proliferation and function (Vandenbroecke et al, 1991)
Fish is a good source of Omega-3 fatty acids, known as polyunsaturated fatty acids (PUFAs), omega-3 fatty acids play a central role in brain function as well as normal growth and development
Our study showed that 6 months of fish oil supplementation does not affect evaluated end points including the concentration of inflammatory marker levels after renal transplantation in Renal transplant recipient (RTR) except on lipid profile
Summary
Amir Hooshang Mohammadpour, Fatemeh Nazemian, Jamal Shamsara, Maryam Bafandegan, Maryam Ghorbani and Seyed Adel Moallem1*. It may be useful to administer this supplement in renal transplant recipients To investigate this possibility, we studied the effect of omega-3 on the occurrence of acute rejection. We assessed the effect of 6 months of dietary supplementation with 6 g/day of omega-3 fatty acids on Lipid profile (TG, HDL-C, and LDL-C) and serum concentration of TNF- , IL-6 and hs-CRP in renal transplant recipients. Based on these data, omega-3 fatty acids supplementation does not cause a decrease in serum level of tested inflammatory biomarkers in renal transplant recipients but decreases total cholesterol level
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