Abstract
Development of novel natural dietary adjunct/agent with significant therapeutic effects on metabolic disease conditions such as obesity and heart disease raises concern in recent times. We studied chronic toxicity of the combined active ingredients present in the sesame leaves and their interaction on the fasting serum lipid profiles with their ratios in thirty adult male non-obese Sprague Dawley (SD) rats. Such that, both treated groups received 14.0 and 28.0 mg/kg body weight doses of aqueous leaves extract of Sesamum radiatum respectively on a daily basis via gastric gavage, while, the control received equal volume of normal saline daily for six weeks. Significant (P and triglycerides (TG). The effect on the serum lipoprotein cholesterol components and ratios were significant in a dose related manner, such that increase in HDL accompanied a corresponding decrease in both LDL and LDL/HDL ratio. In addition, to increased in TG/HDL ratio. However, no significant differences in the relative reduction level of VLDL and triglycerides in the treated groups were found compared to control. Thus, LDL/HDL ratio is significantly a better indicator than the TG/HDL ratio in assessing the impact of sesame treatment with evidence of weight loss and hypolipidaemia especially in hypertensive heart diseases.
Highlights
The development of new dietary adjuncts and novel natural anti-obesity agents with a reducing effect on the long-term complications associated with metabolic syndrome, thereby helping to reinstate a normal metabolic environment in the body have been expressed in recent times
We studied chronic toxicity of the combined active ingredients present in the sesame leaves and their interaction on the fasting serum lipid profiles with their ratios in thirty adult male non-obese Sprague Dawley (SD) rats
As obtained from report of the 1998 National Health Survey (NHS) in England, where excess body weight alone accounted for 47% of the coronary heart disease (CHD) found in these high-risk men (United States Renal Data System, 1998)
Summary
The development of new dietary adjuncts and novel natural anti-obesity agents with a reducing effect on the long-term complications associated with metabolic syndrome, thereby helping to reinstate a normal metabolic environment in the body have been expressed in recent times. Recognized by World Health organization to be among the top 10 global health problem, such that over 1 billion adults are overweight and more than 300 billions are obese, worldwide with a rising incidence from country to country (Marx, 2003). This was corroborated with data from US National Health and Examination Survey in 2003 - 2004, which revealed that 67% of adults are overweight or obese, with 17% of children and adolescents overweight (Ogden et al, 2006). As obtained from report of the 1998 National Health Survey (NHS) in England, where excess body weight alone accounted for 47% of the CHD found in these high-risk men (United States Renal Data System, 1998)
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