Abstract
Several studies have used Stachys Lavandulifolia vahl (S. lavandulifolia) as medicinal plant in Iranian folk medicine. The present investigation is designed to elucidatetherapeutic and preventive effects of S. lavandulifolia extract on gastric acid and pepsin secretions in experimental gastric ulcer. Thirty two Wistar male rats were used to study therapeutic and preventive effects of S. lavandulifolia extract on alcohol-induced gastric ulcer. Animals were equally (n=8) divided into 4 groups: (I) Control (II) Alcohol (1 ml/200 g/bw) to induce gastric ulcer (III) Alcohol/Lvandu (100 mg/kg bw/daily, S. lavandulifoliaextract was given for two weeks post alcohol administration) and (IV) Lvandu/alcohol (S. lavandulifolia extract was given for two weeks before alcohol administration). Ulcer index, gastric acid and pepsin secretions was measured. Ulcer index was significantly decreased in alcohol/Lvandu than Alcohol group. Also gastric acid and pepsin secretions, and gastric tissue’s NO metabolites level were significantly lower in alcohol and Lvandu/alcohol groups than control (p<0/05). But changes in gastric acid and pepsin secretions have not been noticeable in alcohol/Lvandu group than control. The results of this study show that S. lavandulifolia extract protected gastric mucosa from alcohol-induced gastric ulcer. This gastroprotection may mediate via gastric mucosal nitric oxide production. Key words: Stachys Lavandulifolia, acid, pepsin, nitric oxide.
Highlights
Many factors are involved in gastric and duodenal ulcer pathology such as stress, smoking, nutritional deficiencies, alcohol ingestion and nonsteroidal anti-inflammatory drugs (Nash et al, 1994; Basil and Howard, 1995)
Effects of S. lavandulifolia extract on gastric ulcer parameters
Gastric ulcer measurements showed that S. lavandulifolia extract significantly decreased the number of ulcer, ulcer score and index at alcohol/Lvandu than alcohol group (p
Summary
Many factors are involved in gastric and duodenal ulcer pathology such as stress, smoking, nutritional deficiencies, alcohol ingestion and nonsteroidal anti-inflammatory drugs (Nash et al, 1994; Basil and Howard, 1995). Several studies have used Stachys Lavandulifolia vahl (S. lavandulifolia) as medicinal plant in Iranian folk medicine (Ghasemi-Pirbalouti, 2011; Hajhashemi et al, 2007). This plant is widely distributed in different regions of Iran and popularly known as "chaie koohi" (Hajhashemi et al, 2007). Anti-inflammatory and antibacterial effects, and wound healing activity of S. lavandulifolia extract have been shown in several pharmacological studies
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