Abstract
Effective and fast detection of acute diseases is still a main challenge for early diagnosis and monitoring treatment. In this work, surface-enhanced Raman scattering (SERS) probes are incorporated into a microfluidic paper strip for antigen biomarker detection. First, a new material is designed to tune plasmon band position and intensity. Second, geometry is optimized to maximize the SERS enhancement factor. The Finite-Difference Time-Domain simulation has confirmed that more hotspots are generated by the above optimization. As a results, the paper microfluidic strip has achieved the limit of detection at pg/mL level toward antigen detection in blood plasma. The paper microfluidic device shows a great potential in early detection of acute diseases at home, clinics, and remote areas with limited resources.
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