Engineering microorganisms to generate fluorinated platform chemicals

Abstract

In this issue of Chem Catalysis , Wirth and Nikel report a synthetic biology approach to engineering the bacterium Pseudomonas putida to produce 2-fluoro- cis,cis -muconic acid from 3-fluorobenzoate at the maximum theoretical yield. This work provides a biocatalytic strategy to efficiently produce valuable fluorinated compounds that are difficult to obtain synthetically. In this issue of Chem Catalysis , Wirth and Nikel report a synthetic biology approach to engineering the bacterium Pseudomonas putida to produce 2-fluoro- cis,cis -muconic acid from 3-fluorobenzoate at the maximum theoretical yield. This work provides a biocatalytic strategy to efficiently produce valuable fluorinated compounds that are difficult to obtain synthetically.