Abstract
AbstractThe combination of chemo‐ and photothermal therapy is an effective strategy to improve clinical outcomes and minimize side effects. For simultaneously delivering chemo‐ and photothermal agents to the tumor region to exert their synergistic effect, an efficient and safe drug co‐delivery platform is in great need. Microcapsules (MCs) are promising drug carriers for local treatment of tumors. However, their applications in chemo‐photothermal combinational therapy have not been fully explored. Herein, novel doxorubicin (DOX) and indocyanine green (ICG)‐incorporated microcapsules (DIMCs) are reported for highly efficient delivery of combinational therapeutics. To obtain DIMCs with precise configuration and controlled drug release characteristics, the microfluidic double‐emulsion templating method is adopted and factors dominating the size and morphology of DIMCs are investigated. Under optimized conditions, DIMCs with well‐defined hydrogel cores and polymeric shells can be steadily prepared, which are hydrolytically degradable, allow for pH‐sensitive sustained release of the drug payload, and show excellent photothermal effects. The in vitro experiment shows that DIMCs exhibit significantly enhanced antitumor efficiency owing to the synergistic effects of chemo‐ and photothermal actives, showing great potential as a new therapeutic platform in local treatment of cancers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
