Abstract
Abstract : Our long-term goal is to use tools from molecular biology to engineer multi-enzyme metabolic complexes, mimicking the physical forms ubiquitous in nature. The direct coupling between sequential enzymatic reactions, through either static or dynamic interactions, offers the promise of eliminating these production barriers as it reduces the distance between enzyme active sites and favors sequential reactions over diffusion into the bulk. Therefore, the objective of these studies is to engineer synthetic metabolic complexes by exploiting the assembly mechanisms of natural systems to spatially organize enzymes that participate in sequential reaction steps. We expect that by developing a generic set of tools to co-localize metabolic pathways, we will overcome traditional bottlenecks that limit the commercial viability of microbial factories.
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