Abstract
Corneal Cross-Linking ln article number 2109865, Rongrong Gao, Jinhai Huang, Xingtao Zhou, and co-workers report novel engineering of hydrangea-like RF@ZIF-8 microsphere composites with outstanding trans-epithelial corneal cross-linking (TE-CXL) efficacy, suggesting a promising nanomedicine strategy. The described use of the metal–organic framework as carrier to transfer hydrophilic negatively charged Riboflavin-5-phosphate (RF) molecules to the hydrophobic corneal epithelium, with excellent TE-CXL efficacy, may open up a new field of CXL.
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