Engineering Bioartificial Lungs for Transplantation

Abstract

The purposes of this study were to review current progress being made in engineering bioartificial lungs for transplantation and identify tangible benefits to the implementation of this research into development of 4D lung models for disease modeling, drug screening, and personalized medicine that could be realized in the next 5 years. We focused primarily on the generation and analysis of decellularized lung scaffolds, the repopulation of acellular lung scaffolds by primary cells and pluripotent stem cells-derived cells, and current disease modeling approaches. Bioengineered lung has significant potential in transplantation and facilitates future biomedical research by establishing of 4D cell culture model on the scaffold; it will benefit the implementation of the development of disease modeling, drug screening, and personalized medicine.