Abstract
Significant advancement in the field of nanotechnology has raised the possibility of applying potent engineered biocompatible nanomaterials within biological systems for theranostic purposes. Titanium dioxide (titanium(IV) oxide/titania/TiO2) has garnered considerable attention as one of the most extensively studied metal oxides in clinical applications. Owing to the unique properties of titania, such as photocatalytic activity, excellent biocompatibility, corrosion resistance, and low toxicity, titania nanomaterials have revolutionized therapeutic approaches. Additionally, titania provides an exceptional choice for developing innovative medical devices and the integration of functional moieties that can modulate the biological responses. Thus, the current review aims to present a comprehensive and up-to-date overview of TiO2-based nanotherapeutics and the corresponding future challenges.
Highlights
Nanomaterials can be described as any organic, inorganic, or organometallic material whose chemical, physical, and/or electrical properties change as a function of the size and shape of the material
The present review focuses on contemporary research of TiO2 nanoparticles and their clinical applications, including their usage as an implant material, antimicrobial agent, drug delivery vehicle, photothermal therapeutic tool, and antivenom
When a TiO2 nanomaterial circulates through the body, certain biomolecules get adsorbed onto the surface of it very quickly, which is termed as “protein corona (PC)” formation
Summary
Padmavati Sahare1, Paulina Govea Alvarez1, Juan Manual Sanchez Yanez2, Gabriel Luna-Bárcenas3, Samik Chakraborty4, Sujay Paul*5 and Miriam Estevez*1 Address: 1Centre of Applied Physics and Advanced Technologies (CFATA), National Autonomous University of Mexico, Queretaro, Mexico, 2Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Mexico, 3Grupo de Investigación de Biomateriales, Ciencia de los Materiales, Cinvestav, Querétaro, Mexico, 4Division of Nephrology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA and 5Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No 500 Fracc. San Pablo, CP 76130 Querétaro, Mexico Keywords: clinical application; nanostructures; physicochemical; theranostics; titanium dioxide (TiO2) Beilstein J. Nanotechnol. 2022, 13, 201–218. https://doi.org/10.3762/bjnano.13.15
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